|SYMPOSIUM: CERVICAL SPINE TRAUMA
|Year : 2022 | Volume
| Issue : 1 | Page : 4-9
Innovations in cervical spine trauma: Developing the next generation upper cervical spine injury classification system
Brian A Karamian1, Hannah A Levy1, Paul D Minetos1, Michael L Smith2, Alexander R Vaccaro1
1 Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA
2 Rothman Orthopaedics, New York, NY, USA
|Date of Submission||03-Apr-2021|
|Date of Decision||05-Jul-2021|
|Date of Acceptance||30-Jul-2021|
|Date of Web Publication||02-Feb-2022|
Brian A Karamian
Rothman Orthopaedic Institute at Thomas Jefferson University, 925 Chestnut St, 5th Floor, Philadelphia, PA 19107.
Source of Support: None, Conflict of Interest: None
The upper cervical spine not only consists of intricate bony and ligamentous anatomy affording unique flexibility but also has increased susceptibility to injuries. The upper cervical spine trauma can result in a wide spectrum of injuries that can be managed both operatively and nonoperatively. Several existing classification systems have been proposed to describe injuries of the upper cervical spine, many of which rely on anatomic descriptions of injury location. Prior fracture classifications are limited in scope, characterizing fractures restricted to a single region of the upper cervical spine, and fail to provide insight into injury management. The AO Spine Upper Cervical Injury Classification System (AO Spine UCCS) has recently been developed as a comprehensive, yet concise classification scheme to describe all injuries of the upper cervical spine. The AO Spine UCCS represents a significant development in the classification of upper cervical spine injuries, with the potential to serve as a decision-making instrument to aid in patient management.
Keywords: AO spine, classification, fracture, upper cervical
|How to cite this article:|
Karamian BA, Levy HA, Minetos PD, Smith ML, Vaccaro AR. Innovations in cervical spine trauma: Developing the next generation upper cervical spine injury classification system. Indian Spine J 2022;5:4-9
|How to cite this URL:|
Karamian BA, Levy HA, Minetos PD, Smith ML, Vaccaro AR. Innovations in cervical spine trauma: Developing the next generation upper cervical spine injury classification system. Indian Spine J [serial online] 2022 [cited 2022 May 25];5:4-9. Available from: https://www.isjonline.com/text.asp?2022/5/1/4/337139
| Introduction|| |
The upper cervical spine, often referred to as the craniocervical junction, is defined as the anatomic region extending from the occipital condyles to C2. The upper cervical spine protects the brainstem, spinal cord, upper spinal nerve roots, lower cranial nerves, and vasculature involved in posterior cranial circulation. As such, an injury to this area can result in a wide spectrum of injuries from muscular strain to spinal cord injury and death. Because of its critical location supporting the cranium and its unique anatomy allowing for the largest proportion of the total range of motion in the cervical spine, the upper cervical spine is particularly prone to injuries.
Given the complexity of injury patterns seen in upper cervical spine trauma (UCST), prior classification schemes have restricted themselves to descriptions of fracture patterns limited to subregions of the upper cervical spine. These anatomic descriptions facilitate communication of injuries to other providers but fail to provide the conceptual framework required for injury management. The UCST often necessitates surgical intervention, and therefore a comprehensive upper cervical injury classification should help predict clinical outcomes and help guide surgical decision-making. Taking into consideration the most clinically relevant aspects of UCST, the AO Spine Knowledge Forum Trauma recently developed the AO Spine Upper Cervical Classification System (AO Spine UCCS) as a concise and comprehensive scheme to classify UCST. Building on the work of previous AO Spine Subaxial, Thoracolumbar, and Sacral Injury Classification Systems, the AO Spine UCCS represents a significant step toward the development of treatment algorithms for patients with UCST.,,, The purpose of this review is to summarize the previous upper cervical fracture classifications and to highlight the newly developed AO Spine UCCS.
| Anatomy|| |
The upper cervical spine consists of the occiput, atlas, and axis, their synovial articulations, and a complex network of stabilizing ligamentous structures. The role of the upper cervical spine is to bear the weight of the cranium, protect the housed neurologic structures including the medulla oblongata, lower cranial nerves, and upper cervical spinal nerve roots and cord, and provide the majority of flexion, extension, and rotation of the cervical spine., Of the entire cervical spine, the atlantooccipital joint provides the greatest range of motion in the flexion/extension plane, with a total range of motion of approximately 15°–20°, whereas the atlantoaxial complex accounts for the majority of the cervical spine’s axial rotation, between approximately 29° and 46° in each lateral direction.,,,, Given that the weight-bearing load across the upper cervical spine is less than that experienced by the remainder of the spine, vertebral body size and segmental motion are ideal to compensate for the increased range of motion experienced in this region of the skeleton. Stability in this region is achieved through a ligamentous framework rather than bony morphology. As a result, the ligaments of the upper cervical spine are more robust with higher loads to failure when compared with the ligaments of the lower cervical spine. However, this unique flexibility and intricate bony and ligamentous anatomy make the upper cervical spine vulnerable to injuries.
| Prior Classification Systems|| |
Existing and historical upper cervical fracture classification systems are detailed in [Table 1]. Early UCST classification schemas concentrated on anatomic location in describing fracture patterns and failed to incorporate ligamentous injuries, significantly limiting the ability of these classification systems to guide clinical management. Subsequent classifications have served as modifications of early classification systems, incorporating injury morphology, mechanism, and ligamentous status. However, the utility of these systems is limited by their scope addressing only subregions within the upper cervical spine. Accordingly, a new upper cervical injury classification system has been developed to be concise, reproducible, universally applicable throughout the upper cervical spine and ultimately serve as the foundation for clinical decision-making.
| New Classification System|| |
AO Spine UCCS
With the ultimate goal of optimizing patient outcomes and standardizing UCST management, the AO Spine Knowledge Forum Trauma has recently developed a classification system for upper cervical spine injuries that has proven to be an encompassing scheme incorporating the most clinically relevant factors of the aforementioned classification systems. The development of the AO Spine UCCS follows a similar methodology to the previously described development of AO Spine Thoracolumbar and Sacral Injury Classification Systems.,, Under the guidance of a coordinating methodologist, 10 experienced internationally trained spine trauma surgeons participated in a structured consensus method to develop and refine the AO Spine UCCS. Agreement among surgeons was analyzed using latent class modeling, and the reasons for disagreement were systematically revised iteratively during review meetings until consensus was reached among all surgeons.
Similar to the AO Spine Subaxial, Thoracolumbar, and Sacral Injury Classification Systems, the AO Spine UCCS utilizes an alphanumerical nomenclature based on the injury type and severity.,,, The classification scheme’s hierarchical nature allows for prompt stratification of injury severity. In addition to classifying the injury type and location, the AO Spine UCCS also takes into consideration patient-level factors relevant to patient management, as well as neurologic status at the time of presentation.,,
The first node in the classification of the upper cervical spine injury using the AO Spine UCCS is based on the anatomic location of the injury. The three anatomic locations are defined by the condyle/vertebra and its caudal joint. Category I injuries involve the occipital condyle and craniocervical junction. Category II injuries involve the C1 ring and C1–2 joint. Lastly, Category III injuries involve the C2 body and C2–3 joint. From there, injuries are further subclassified by the mechanism of the injury and its inherent instability. Type A injuries represent isolated bony injuries that do not involve injuries of the surrounding soft tissues or intervertebral disc. As a result, these injuries are inherently stable and typically do not require surgery. Type B injuries are defined by tension band and ligamentous injuries with or without bony injury, which may or may not be stable depending on the injury characteristics. Angular deformity injuries that do not involve translation, such as an atypical Hangman’s fracture, are classified as Type B, which may or may not require surgical stabilization. Lastly, Type C injuries include translational, rotational, or distraction injuries through the joint or disc space in any direction. These injuries are inherently unstable and require surgical management.
| Category I: Occipital Condyle and Craniocervical Junction|| |
Injuries of the occipital condyle and craniocervical junction are least common and are depicted in [Figure 1]. Type IA injuries involve a fracture of the occipital condyle without an associated ligamentous injury or craniocervical dislocation. Type IB injuries involve nondisplaced ligamentous injuries of the craniocervical junction and are the only injury type of the classification that requires MRI to confirm the diagnosis. Lastly, Type IC injuries involve displacement through the craniocervical junction, including both distraction and translational injuries [Figure 1].
| Category II: C1 Ring and C1–2 Joint|| |
Injuries of the C1 ring and C1–2 joint include injuries to the bony arch (Type IIA), ligamentous injury of the transverse atlantal ligament (Type IIB), and atlantoaxial instability (Type IIC). Type A injuries are stable and can typically be managed nonoperatively. An injury to the transverse ligament in Type IIB burst injury is indicated by lateral mass overhang visible on both coronal computed tomography (CT) sequences and also on open mouth AP radiographs. Lastly, Type IIC injuries represent significant atlantoaxial instability with a rotational or translational injury with risk of neurologic injury requiring surgical intervention [Figure 2].
| Category III: C2 and C2–3 Joint|| |
Injuries of C2 and the C2–3 joint are the most common injuries within the upper cervical spine. Type IIIA injuries include bony injuries of the axis, including the dens, pedicle, pars interarticularis, and lamina. Unlike most Type A injuries (i.e., Type IA and IIA injuries), Type IIIA injuries may need to be managed operatively depending on the fracture pattern, amount of displacement, and patient neurologic status. Type IIIB injuries are defined by disruption of the posterior tension band with associated injury to the intervertebral disc. Important to note, angulation through the C2–3 joint represents Type IIIB injuries, whereas angulation through fractures of the odontoid represents Type IIIA injury. Complete translation occurring through the C2–3 joint represents a Type IIIC injury [Figure 3].
| Modifiers|| |
Similar to the AO Spine Subaxial, Thoracolumbar, and Sacral Injury Classification systems, the AO Spine UCCS incorporates clinically relevant variables shown to affect patient management and outcomes as patient-specific modifiers. Injuries that are at high risk of nonunion with nonoperative management have the M1 modifier. For example, this would include patients with Type IIIA angulated and displaced fractures through the waist of the odontoid or patients initially treated nonoperatively with subsequent displacement on follow-up imaging. Injuries that are likely to be unstable, such as a displaced C1 unilateral lateral mass fracture, have the M2 modifier. Comorbidities and patient characteristics that pose difficulties for injury management, including age, smoking status, and pertinent medical history such as ankylosing spondylitis, are incorporated using the M3 modifier. Finally, vascular injury or vertebral artery abnormalities that affect treatment are incorporated in the M4 modifier.
| Neurology|| |
Neurologic status plays a critical role in the management of spinal trauma patients, where patients with injuries that may be otherwise managed nonoperatively require surgical decompression and stabilization due to neurologic compromise. Accordingly, the AO Spine has used the same neurology classifiers across all subaxial, thoracolumbar, and sacral classifications systems.,,, N0 defines neurologically intact patients. Patients with transient neurologic deficits and those with radicular symptoms are classified as N1 and N2, respectively. Patients with incomplete spinal cord injury are classified as N3, and patients with complete spinal cord injury are classified as N4. Patients who are either obtunded/unconscious or otherwise unable to be examined are considered NX. Lastly, a “+” indicates continued spinal cord compression in patients with neurologic compromise.
| Validation|| |
In the only study validating the AO Spine UCCS, “almost perfect” interobserver reliability (k = 0.862/0.884, first/second assessment), as well as intraobserver reproducibility, was found when 32 cases were evaluated by four residents (k = 0.830–0.999) and four senior spine surgeons (k = 0.861–0.999) for fracture sites I, II, and III. For subtype A, B, and C, interobserver reliability was “substantial” (k = 0.660/0.603, first/second assessment), and intraobserver reproducibility ranged from “substantial” to “almost perfect” (k = 0.691–0.920) for residents and “almost perfect” (k = 0.841–0.983) for senior spine surgeons. As is the ultimate goal with any injury classification system, treatment must follow injury categorization. When surveying treatment recommendations based on the AO Spine UCCS classification, reliability ranged from “substantial” (k = 0.679/0.751) for residents to “almost perfect” (k = 0.982/0.963) for spine surgeons. These observed reliability scores lend credence to the AO Spine UCCS as a dependable resource for classification and decision-making with regard to patients with the upper cervical spine injury but require further validation.
| Future Directions|| |
The precedent for validation methodology has been previously established in all AO Spine classifications, including the AO Spine Subaxial and Thoracolumbar Classification Systems.,,,,,,, The aforementioned study of the AO Spine UCCS, while promising, represents a pilot validation examining the reliability of the classification system among a small number of users with various levels of training. Further work is ongoing, including a multicenter agreement study using a large number of representative cases and raters of various levels of expertise globally to complete intermediate validation. Following the results, further refinement and improvement of the classification system will be performed before proceeding to advanced validation to include injury severity assessment, score assignment, and the development of a surgical algorithm using threshold values.
| Conclusion|| |
The AO Spine UCCS represents a significant advancement in the classification of UCST and lays the groundwork for future treatment algorithms. Unlike the numerous existing and overlapping upper cervical classification systems, the AO Spine UCCS is a concise, comprehensive, and reliable classification scheme that is universal to the entire upper cervical spine. Ultimately following advanced validation, an accompanying scoring system with clinically relevant cutoff values will be developed to standardize the treatment of upper cervical injuries and help drive higher-level studies for the management of UCST.
Ethical policy and institutional review board statement
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
White AA, Punjabi MM Kinematics of the Spine, Clinical Biomechanics of the Spine. 2nd ed. Philadelphia, PA: Lippincott; 1990.
Vaccaro AR, Koerner JD, Radcliff KE, Oner FC, Reinhold M, Schnake KJ, et al
. AOspine subaxial cervical spine injury classification system. Eur Spine J 2016;25:2173-84.
Schnake KJ, Schroeder GD, Vaccaro AR, Oner C Aospine classification systems (subaxial, thoracolumbar). J Orthop Trauma 2017;31(Suppl 4):14-23.
Vaccaro AR, Oner C, Kepler CK, Dvorak M AOspine thoracolumbar spine injury classification system. Spine 2013;38:2028-37.
Vaccaro AR, Schroeder GD, Divi SN, Kepler CK, Kleweno CP, Krieg JC, et al
. Description and reliability of the AOspine sacral classification system. J Bone Joint Surg Am 2020;102:1454-63.
Kaiser JT, Reddy V, Lugo-Pico JG Anatomy, Head and Neck, Cervical Vertebrae. Treasure Island, FL: StatPearls Publishing; 2020.
Menezes AH, Traynelis VC Anatomy and biomechanics of normal craniovertebral junction (a) and biomechanics of stabilization (b). Childs Nerv Syst 2008;24:1091-100.
Joaquim AF, Ghizoni E, Tedeschi H, Lawrence B, Brodke DS, Vaccaro AR, et al
. Upper cervical injuries—A rational approach to guide surgical management. J Spinal Cord Med 2014;37:139-51.
Goel A, Bhatjiwale M, Desai K Basilar invagination: A study based on 190 surgically treated patients. J Neurosurg 1998;88:962-8.
Penning L, Wilmink JT Rotation of the cervical spine. A CT study in normal subjects. Spine (Phila Pa 1976) 1987;12:732-8.
Bogduk N, Mercer S Biomechanics of the cervical spine. I: Normal kinematics. Clin Biomech (Bristol, Avon) 2000;15:633-48.
Anderson PA, Montesano PX Morphology and treatment of occipital condyle fractures. Spine (Phila Pa 1976) 1988;13:731-6.
Tuli S, Tator CH, Fehlings MG, Mackay M Occipital condyle fractures. Neurosurgery 1997;41:368-76; discussion 376-7.
Traynelis VC, Marano GD, Dunker RO, Kaufman HH Traumatic atlanto-occipital dislocation. Case report. J Neurosurg 1986;65:863-70.
Bellabarba C, Mirza SK, West GA, Mann FA, Dailey AT, Newell DW, et al
. Diagnosis and treatment of craniocervical dislocation in a series of 17 consecutive survivors during an 8-year period. J Neurosurg Spine 2006;4:429-40.
Jefferson G Fracture of the atlas vertebra. Report of four cases, and a review of those previously recorded. Brit J Surg 1919;7:407-22.
Dickman CA, Greene KA, Sonntag VK Injuries involving the transverse atlantal ligament: Classification and treatment guidelines based upon experience with 39 injuries. Neurosurgery 1996;38:44-50.
Anderson LD, D’Alonzo RT Fractures of the odontoid process of the axis. J Bone Joint Surg Am 1974;56:1663-74.
Grauer JN, Shafi B, Hilibrand AS, Harrop JS, Kwon BK, Beiner JM, et al
. Proposal of a modified, treatment-oriented classification of odontoid fractures. Spine J 2005;5:123-9.
Effendi B, Roy D, Cornish B, Dussault RG, Laurin CA Fractures of the ring of the axis. A classification based on the analysis of 131 cases. J Bone Joint Surg Br 1981;63-B:319-27.
Levine AM, Edwards CC The management of traumatic spondylolisthesis of the axis. J Bone Joint Surg Am 1985;67:217-26.
Starr JK, Eismont FJ Atypical hangman’s fractures. Spine (Phila Pa 1976) 1993;18:1954-7.
Benzel EC, Hart BL, Ball PA, Baldwin NG, Orrison WW, Espinosa M Fractures of the C-2 vertebral body. J Neurosurg 1994;81:206-12.
Fujimura Y, Nishi Y, Kobayashi K Classification and treatment of axis body fractures. J Orthop Trauma 1996;10:536-40.
Reinhold M, Audigé L, Schnake KJ, Bellabarba C, Dai LY, Oner FC AOspine injury classification system: A revision proposal for the thoracic and lumbar spine. Eur Spine J 2013;22:2184-201.
Kepler CK, Vaccaro AR, Koerner JD, Dvorak MF, Kandziora F, Rajasekaran S, et al
. Reliability analysis of the AOspine thoracolumbar spine injury classification system by a worldwide group of naïve spinal surgeons. Eur Spine J 2016;25:1082-6.
Bellabarba C, Schroeder GD, Kepler CK, Kurd MF, Kleweno CP, Firoozabadi R, et al
. The AOSpine sacral fracture classification. Global Spine J2016;6(1_suppl).
Vaccaro AR, Lim MR, Hurlbert RJ, Lehman RA Jr, Harrop J, Fisher DC, et al
; Spine Trauma Study Group. Surgical decision making for unstable thoracolumbar spine injuries: Results of a consensus panel review by the spine trauma study group. J Spinal Disord Tech 2006;19:1-10.
Maeda FL, Formentin C, de Andrade EJ, Rodrigues PAS, Goyal DKC, Shroeder GD, et al
. Reliability of the new AOspine classification system for upper cervical traumatic injuries. Neurosurgery 2020;86:E263-70.
Divi SN, Schroeder GD, Goyal DKC, Radcliff KE, Galetta MS, Hilibrand AS, et al
. Fusion technique does not affect short-term patient-reported outcomes for lumbar degenerative disease. Spine J 2019;19:1960-8.
Spence KF Jr, Decker S, Sell KW Bursting atlantal fracture associated with rupture of the transverse ligament. J Bone Joint Surg Am 1970;52:543-9.
Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak MF, et al
. Establishing the injury severity of thoracolumbar trauma: Confirmation of the hierarchical structure of the AOspine thoracolumbar spine injury classification system. Spine (Phila Pa 1976) 2015;40:E498-503.
Vaccaro AR, Schroeder GD, Kepler CK, Cumhur Oner F, Vialle LR, Kandziora F, et al
. The surgical algorithm for the AOspine thoracolumbar spine injury classification system. Eur Spine J 2016;25:1087-94.
Kepler CK, Vaccaro AR, Schroeder GD, Koerner JD, Vialle LR, Aarabi B, et al
. The thoracolumbar AOspine injury score. Global Spine J 2016;6:329-34.
Schroeder GD, Canseco JA, Patel PD, Divi SN, Karamian BA, Kandziora F, et al
. Establishing the injury severity of subaxial cervical spine trauma: Validating the hierarchical nature of the AO Spine subaxial cervical spine injury classification system. Spine (Phila Pa 1976) 2021;46:649-57.
Canseco JA, Schroeder GD, Paziuk TM, Karamian BA, Kandziora F, Kandziora F, et al
. The subaxial cervical AO Spine injury score. Global Spine J 2020:219256822097433.
[Figure 1], [Figure 2], [Figure 3]